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| Ex Vivo Metrics™: How Drug Studies in Reanimated Human Organs Could Revitalize the Drug Development Process
An editorial by Gerald Curtis, PhD
Fallout from the catastrophic phase I clinical trial of TeGenero’s monoclonal antibody TGN1412 in March 2006,1 in which 6 volunteers suffered life-threatening “cytokine storms,” includes newly tightened regulations in the United Kingdom and renewed concern worldwide about first-in-human trials, particularly for compounds with novel targets or mechanisms of action.
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Editorials
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| DNA
Genotyping from human FFPE Samples |
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In this feasibility study, Applied Biosystems demonstrates how the combined
use Recover All Total Nucleic |
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Acid Isolation Kit and TaqMan SNP Genotyping
Assay can result in high quality, reproducible, and reliable genotyping
data.. Read
more |
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Millipore has
launched the CellCiphr Cytotoxicity Profiling Assay Kit
using human HepG2 cells. This assay panel detects
drug-induced hepatotoxicity and is expected to be used
early in the drug discovery process. read
more
Cartesian Gridspeed, Ltd. announced the
opening of its new sales, marketing and technical support
subsidiary, SLIM Search, Inc. in Mission Viejo,
California. SLIM
Search, Inc. is marketing
its SLIM Search genomic search tool to universities,
government research, and research and development
departments of biotechnology corporations and individual
contributors. read
more
The new Variant Reporter Software from Applied
Biosystems automates detection of variants and
streamlines data analysis process. The software uses
proprietary algorithms to identify genetic variations
based on standardized or user-defined parameters. Results
are presented for validation in a visual format that
allows researchers to simultaneously compare multiple
quality control metrics. More information and a free trial
version are available at:
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more
More
Products
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| We invite your comments and feedback for this edition of Biomarker Breakthroughs. Email us at
maloryea@gmail.com |
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NEW -
Summer 07, Yihan Wang of on "Challenges Developing
Kinase Inhibitors" ARIAD Pharmaceuticals, Inc. - view webcast
NEW -
Summer 07,
Neil W Gibson of OSI Pharmaceuticals on
"Finding Responders to EGFR
Inhibitors and Future Directions for Development"
- view webcast
NEW - Summer
07, Dr. Jeffrey Settleman, Harvard Medical School and MGH Cancer Center. "
Kinase Inhibition: The Role of Oncogenic Shock and A High Throughput System
for Analyzing Sensitivity"
- view webcast
NEW - Summer
07, David Bailey of Chemoventures on:
"Breakthroughs in Structure-Based Drug
Design: Implications for Drug Discovery and Development"
- view webcast
NEW - Summer
07, N Claude Cohen of Synergix on
"Critical Contributions of Structure Based
Drug Design: Renin Inhibitors"
- view webcast
Spring 07, CHI's G.O.T
Summit - James L. Wittliff, Ph.D., M.D. hc, Professor
of Biochemistry & Molecular Biology, James Graham
Brown Cancer Center, University of Louisville
- view webcast
Spring 07, CHI's G.O.T
Summit - Scott D. Patterson, Ph.D., Senior Director, Medical Sciences, Amgen Inc.
- view webcast
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