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| Ex Vivo Metrics™: How Drug Studies in Reanimated Human Organs Could Revitalize the Drug Development Process
An editorial by Gerald Curtis, PhD
Fallout from the catastrophic phase I clinical trial of TeGenero’s monoclonal antibody TGN1412 in March 2006,1 in which 6 volunteers suffered life-threatening “cytokine storms,” includes newly tightened regulations in the United Kingdom and renewed concern worldwide about first-in-human trials, particularly for compounds with novel targets or mechanisms of action.
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Editorials
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| DNA
Genotyping from human FFPE Samples |
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In this feasibility study, Applied Biosystems demonstrates how the combined
use Recover All Total Nucleic |
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Acid Isolation Kit and TaqMan SNP Genotyping
Assay can result in high quality, reproducible, and reliable genotyping
data.. Read
more |
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Millipore has
launched the CellCiphr Cytotoxicity Profiling Assay Kit
using human HepG2 cells. This assay panel detects
drug-induced hepatotoxicity and is expected to be used
early in the drug discovery process. read
more
Cartesian Gridspeed, Ltd. announced the
opening of its new sales, marketing and technical support
subsidiary, SLIM Search, Inc. in Mission Viejo,
California. SLIM
Search, Inc. is marketing
its SLIM Search genomic search tool to universities,
government research, and research and development
departments of biotechnology corporations and individual
contributors. read
more
The new Variant Reporter Software from Applied
Biosystems automates detection of variants and
streamlines data analysis process. The software uses
proprietary algorithms to identify genetic variations
based on standardized or user-defined parameters. Results
are presented for validation in a visual format that
allows researchers to simultaneously compare multiple
quality control metrics. More information and a free trial
version are available at:
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more
More
Products
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| We invite your comments and feedback for this edition of Biomarker Breakthroughs. Email us at
maloryea@gmail.com |
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IN THIS ISSUE - STRATEGY
NEWS BRIEFS
CALENDAR
Biomarker
World Congress 2007,
May 15–17, Philadelphia, PA
Trends in Pharmaceutical Development
World
Pharmaceutical Congress,
June 12–13, Philadelphia, PA
Dedicated
to All Areas of Biomarker
Research Spanning the
Pharmaceutical and Diagnostic
Pipeline
Beyond
Genome 2007,
June 20–22, San Francisco, CA
Top
Ten Challenges in the
Post-Genome Era
Thermo
Fisher EI/CI Interpretation
Module,
July 31–August 2, West Palm
Beach, FL This comprehensive
course, by the Thermo Fisher
Scientific Training Institute,
will introduce the underlying
principles of
"classical" mass
spectrometry and more.
Basic
Gas Chromatography,
August 21–22 or October 23–24,
West Palm Beach, FL
Designed
for those with little to no
chromatography experience, this
course is the perfect starting
place for those who want to
explore the key fundamentals
and components associated with
gas chromatography.
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