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| Ex Vivo Metrics™: How Drug Studies in Reanimated Human Organs Could Revitalize the Drug Development Process
An editorial by Gerald Curtis, PhD
Fallout from the catastrophic phase I clinical trial of TeGenero’s monoclonal antibody TGN1412 in March 2006,1 in which 6 volunteers suffered life-threatening “cytokine storms,” includes newly tightened regulations in the United Kingdom and renewed concern worldwide about first-in-human trials, particularly for compounds with novel targets or mechanisms of action.
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Editorials
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| DNA
Genotyping from human FFPE Samples |
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In this feasibility study, Applied Biosystems demonstrates how the combined
use Recover All Total Nucleic |
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Acid Isolation Kit and TaqMan SNP Genotyping
Assay can result in high quality, reproducible, and reliable genotyping
data.. Read
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Millipore has
launched the CellCiphr Cytotoxicity Profiling Assay Kit
using human HepG2 cells. This assay panel detects
drug-induced hepatotoxicity and is expected to be used
early in the drug discovery process. read
more
Cartesian Gridspeed, Ltd. announced the
opening of its new sales, marketing and technical support
subsidiary, SLIM Search, Inc. in Mission Viejo,
California. SLIM
Search, Inc. is marketing
its SLIM Search genomic search tool to universities,
government research, and research and development
departments of biotechnology corporations and individual
contributors. read
more
The new Variant Reporter Software from Applied
Biosystems automates detection of variants and
streamlines data analysis process. The software uses
proprietary algorithms to identify genetic variations
based on standardized or user-defined parameters. Results
are presented for validation in a visual format that
allows researchers to simultaneously compare multiple
quality control metrics. More information and a free trial
version are available at:
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Products
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| We invite your comments and feedback for this edition of Biomarker Breakthroughs. Email us at
maloryea@gmail.com |
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New Service for RNA Isolation and Preparation from Whole Blood
Agencourt Bioscience, NuGEN Technologies, and Affymetrix Clinical Services Laboratory (ACSL) have launched a joint service for automated RNA isolation and target preparation from whole blood samples collected in PAXgene Blood Tubes. This service supports expression analysis profiling using Affymetrix GeneChip technology for drug discovery and development, including biomarker discovery, screening, and cancer research. This service automates the Agencourt RNAdvance Blood chemistry and NuGEN’s Ovation Whole Blood Solution for RNA amplification and labeling, which utilizes the Agencourt RNAClean Kit and the Agencourt SPRIPlate 96R Magnet Plate. (Agencourt Bioscience is a wholly-owned subsidiary of Beckman Coulter, Inc.) The complete workflow delivers high yields from small RNA samples, while eliminating the need for certain steps, such as globin reduction and column purification. Automation is carried out with Beckman Coulter’s ArrayPLEX application on the Biomek FX Liquid Handling Workstation. For more, see company
press
release.
Launching a new product?
Send new product announcements to maloryea@gmail.com.
In your e-mail please indicate why your announcement is relevant to readers of Biomarker Breakthroughs.
5-02- 07 - Biomarker Breakthroughs
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