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| Ex Vivo Metrics™: How Drug Studies in Reanimated Human Organs Could Revitalize the Drug Development Process
An editorial by Gerald Curtis, PhD
Fallout from the catastrophic phase I clinical trial of TeGenero’s monoclonal antibody TGN1412 in March 2006,1 in which 6 volunteers suffered life-threatening “cytokine storms,” includes newly tightened regulations in the United Kingdom and renewed concern worldwide about first-in-human trials, particularly for compounds with novel targets or mechanisms of action.
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Editorials
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| DNA
Genotyping from human FFPE Samples |
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In this feasibility study, Applied Biosystems demonstrates how the combined
use Recover All Total Nucleic |
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Acid Isolation Kit and TaqMan SNP Genotyping
Assay can result in high quality, reproducible, and reliable genotyping
data.. Read
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Millipore has
launched the CellCiphr Cytotoxicity Profiling Assay Kit
using human HepG2 cells. This assay panel detects
drug-induced hepatotoxicity and is expected to be used
early in the drug discovery process. read
more
Cartesian Gridspeed, Ltd. announced the
opening of its new sales, marketing and technical support
subsidiary, SLIM Search, Inc. in Mission Viejo,
California. SLIM
Search, Inc. is marketing
its SLIM Search genomic search tool to universities,
government research, and research and development
departments of biotechnology corporations and individual
contributors. read
more
The new Variant Reporter Software from Applied
Biosystems automates detection of variants and
streamlines data analysis process. The software uses
proprietary algorithms to identify genetic variations
based on standardized or user-defined parameters. Results
are presented for validation in a visual format that
allows researchers to simultaneously compare multiple
quality control metrics. More information and a free trial
version are available at:
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Products
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| We invite your comments and feedback for this edition of Biomarker Breakthroughs. Email us at
maloryea@gmail.com |
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BigDye XTerminator, a Reagent Kit for DNA Sequencing, launched by ABI
Applied Biosystems, an Applera Corporation Business, announced a new reagent kit designed to improve the workflow for DNA sequencing. The BigDye XTerminator Purification Kit addresses the purification or ‘clean-up’ step in the Sanger Sequencing workflow to produce higher quality DNA sequence data faster and with significantly fewer steps than other purification methods. Part of the workflow in Sanger Sequencing includes a clean-up step to remove by-products of the sequencing reaction from the labelled DNA fragments. If these by-products are not removed, they can result in shorter sequence read lengths and what scientists refer to as dye blobs, making it difficult to accurately interpret results or obtain high quality data. The BigDye XTerminator Purification Kit is designed to shorten the amount of time and work required to perform the purification step, and to do so in a manner that is more reliable than other available methods. For example, a commonly employed method of DNA purification is ethanol precipitation, which uses ethanol to separate DNA from the unwanted by-products of the sequencing reaction. This particular method involves nearly a dozen steps taking an hour or more, and does not guarantee dye blob removal. As a result, sequencing reactions frequently must be repeated in order to obtain accurate results. For more, see
ABI press
release.
Launching a new product?
Send new product announcements to maloryea@gmail.com.
In your e-mail please indicate why your announcement is relevant to readers of Biomarker Breakthroughs.
3-21- 07 - Biomarker Breakthroughs
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